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SYT8

Synaptotagmin VIII

SYT8 is a member of the synaptotagmin protein family. Synaptotagmins are membrane proteins that are important in neurotransmission and hormone secretion, both of which involve regulated exocytosis. Expression of the encoded protein in human pancreatic islets has been connected to activity of the promoter for the insulin gene, on the same chromosome several hundred kilobases away (PMID: 21336277 and 22928559). This association would link response to gluclose to insulin secretion. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: Synaptotagmin VIII
Synonyms: SYT8, Synaptotagmin 8, Synaptotagmin VIII, SytVIII, Synaptotagmin-8
Target Sequences: AL137708 CAB70885.2 Q8NBV8

Publications (1)

1
SYT8 promotes pancreatic cancer progression via the TNNI2/ERRa/SIRT1 signaling pathway. Zhiping Fu , Xing Liang , Ligang Shi, Liang Tang, Danlei Chen, Anan Liu, Chenghao Shao. Cell death discovery. 2021 December;7:390. [Full Text Article] [PubMed:34907162] [PMC:PMC8671424] Related Antibodies: LS-C161657.

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SYT8 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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20 µg/$150
SYT8 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).