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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SYN1 / Synapsin 1

synapsin I

SYN1 / Synapsin 1 is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Name: synapsin I
Family/Subfamily: Synapsin
Synonyms: SYN1, Brain protein 4.1, Synapsin, Synapsin I, Synapsin-1, SYN1a, SYN1b, SYNI
Target Sequences: NM_006950 NP_008881.2 P17600

Filtered By: None
Target
SYN1 / Synapsin 1 (81)
Reactivity
Human (55)
Mouse (50)
Rat (60)
Bovine (12)
Dog (3)
Horse (1)
Monkey (1)
Pig (2)
Rabbit (1)
Xenopus (3)
Application
IHC (35)
IHC-Fr (2)
IHC-P (15)
WB (77)
Flo (1)
ELISA (22)
ICC (7)
IF (17)
IP (6)
Peptide-ELISA (7)
Host
rabbit (78)
mouse (3)
Isotype
IgG (54)
IgG1 (2)
IgG2a,k (1)
Clonality
monoclonal mc (4)
polyclonal pc (77)
Clone
1D10 (1)
7B1D9 (1)
7H10G6 (1)
Format
AP Conjugated (2)
APC (1)
APC Conjugated (3)
Biotin Conjugated (5)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (4)
PE Conjugated (3)
Unconjugated (57)
Epitope
pSer603 (15)
aa113-420 (11)
pSer9 (10)
pSer62 (3)
1-80 aa (2)
40-120 aa (2)
550-630 aa (2)
pSer553 (2)
N-Terminus (1)
Ser9 (1)
Tyr3 (1)
aa26-75 (1)
aa504-553 (1)
aa576-625 (1)
aa583-600 (1)
aa668-697 (1)
pSer549 (1)
pSer605 (1)
Publications
No (81)
Showing 1-25 of 81 results

SYN1 / Synapsin 1 Antibody IHC-plus™ LS-B6302
Rabbit Monoclonal (IgG) to Human SYN1 / Synapsin 1
Mouse, Rat, Human
IF IHC IHC-P IP WB
Unconjugated
50µl  $425.00
Anti-SYN1 / Synapsin antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Anti-SYN1 / Synapsin antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.

SYN1 / Synapsin 1 Antibody (phospho-Ser605) LS-C199625
Rabbit Polyclonal (IgG) to Human SYN1 / Synapsin 1
Mouse, Rat, Human
IF IHC IHC-P Peptide-ELISA
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human brain, using Synapsin1 (Phospho-Ser605) Antibody. The picture on the right is blocked with the phospho peptide.
Immunofluorescence analysis of COS7 cells, using Synapsin1 (Phospho-Ser605) Antibody. The picture on the right is blocked with the phospho peptide.
Immunohistochemistry analysis of paraffin-embedded human brain, using Synapsin1 (Phospho-Ser605) Antibody. The picture on the right is blocked with the phospho peptide.
Immunofluorescence analysis of COS7 cells, using Synapsin1 (Phospho-Ser605) Antibody. The picture on the right is blocked with the phospho peptide.

SYN1 / Synapsin 1 Antibody (aa576-625) LS-C117933
Rabbit Polyclonal (IgG) to Human SYN1 / Synapsin 1
Mouse, Rat, Human
IF IHC IHC-P Peptide-ELISA
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Synapsin1 Antibody. The picture on the right is blocked with the synthesized peptide.
Immunofluorescence analysis of COS7 cells, using Synapsin1 Antibody. The picture on the right is blocked with the synthesized peptide.
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Synapsin1 Antibody. The picture on the right is blocked with the synthesized peptide.
Immunofluorescence analysis of COS7 cells, using Synapsin1 Antibody. The picture on the right is blocked with the synthesized peptide.

SYN1 / Synapsin 1 Antibody (clone 7H10G6) LS-C669467
Mouse Monoclonal [clone 7H10G6] (IgG1) to Human SYN1 / Synapsin 1
Human
ELISA Flo IF IHC WB
Unconjugated
0.1mg  $365.00

SYN1 / Synapsin 1 Antibody (phospho-Ser9) LS-C354092
Rabbit Polyclonal to Human SYN1 / Synapsin 1
Mouse, Dog, Bovine, Rat, Pig, Human
ICC IF IHC IHC-P WB
Unconjugated
100µl 1mg/ml  $265.00
Immunohistochemical analysis of Synapsin 1 (pS9) staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of Synapsin 1 (pS9) staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Immunohistochemical analysis of Synapsin 1 (pS9) staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of Synapsin 1 (pS9) staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

SYN1 / Synapsin 1 Antibody (N-Terminus) LS-C413173
Rabbit Polyclonal to Human SYN1 / Synapsin 1
Mouse, Dog, Bovine, Rat, Pig, Human
ICC IF IHC IHC-P WB
Unconjugated
100µl 1mg/ml  $275.00
Immunohistochemical analysis of Synapsin 1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of Synapsin 1 staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Immunohistochemical analysis of Synapsin 1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of Synapsin 1 staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

SYN1 / Synapsin 1 Antibody (phospho-Ser9) LS-C132327
Rabbit Polyclonal (IgG) to Human SYN1 / Synapsin 1
Mouse, Rat, Human
WB
Unconjugated
50µg 1mg/ml  $435.00

SYN1 / Synapsin 1 Antibody (phospho-Ser62) LS-C352908
Rabbit Polyclonal to Human SYN1 / Synapsin 1
Mouse, Rat, Human
WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot analysis of Synapsin 1 (pS62) expression in SKNSH nocodazole-treated (A); mouse brain (B); rat brain (C) whole cell lysates.
Western blot analysis of Synapsin 1 (pS62) expression in SKNSH nocodazole-treated (A); mouse brain (B); rat brain (C) whole cell lysates.

SYN1 / Synapsin 1 Antibody (aa113-420) IHC-plus™ LS-B13819
Rabbit Polyclonal (IgG) to Human SYN1 / Synapsin 1
Human
ELISA IHC IHC-P WB
Unconjugated
50µg  $425.00
Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SYN1 / Synapsin 1 Antibody (Ser9) LS-C39352
Rabbit Polyclonal (IgG) to Human SYN1 / Synapsin 1
Mouse, Rat, Human
ELISA IF IHC IHC-Fr WB
Unconjugated
100µl  $530.00

SYN1 / Synapsin 1 Antibody (1-80 aa) LS-C386249
Rabbit Polyclonal (IgG) to Human SYN1 / Synapsin 1
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of Synapsin I antibody
Western blot of Synapsin I antibody

SYN1 / Synapsin 1 Antibody (1-80 aa) LS-C380848
Rabbit Polyclonal (IgG) to Human SYN1 / Synapsin 1
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of Phospho-Synapsin I (S9) antibody
Western blot of Phospho-Synapsin I (S9) antibody
Western blot of Phospho-Synapsin I (S9) antibody
Western blot of Phospho-Synapsin I (S9) antibody

SYN1 / Synapsin 1 Antibody (phospho-Ser603) LS-C222
Rabbit Polyclonal to Rat SYN1 / Synapsin 1
Xenopus, Rat, Mouse, Bovine, Human
WB
Unconjugated
100µl  $375.00
Western blot of rat brain lysate showing specific immunolabeling of the ~78k synapsin I phosphorylated at Ser603 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: l-Ptase). The blot is identical to the control except that it was incubated in l-Ptase (1200 units for 30 min) before being exposed to the Anti-Phospho-Ser603 synapsin I. The immunolabeling is completely eliminated by treatment with l-Ptase.
Western blot of rat brain lysate showing specific immunolabeling of the ~78k synapsin I phosphorylated at Ser603 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: l-Ptase). The blot is identical to the control except that it was incubated in l-Ptase (1200 units for 30 min) before being exposed to the Anti-Phospho-Ser603 synapsin I. The immunolabeling is completely eliminated by treatment with l-Ptase.

SYN1 / Synapsin 1 Antibody (aa668-697) IHC-plus™ LS-B10698
Rabbit Polyclonal to Human SYN1 / Synapsin 1
Human
IHC IHC-P WB
Unconjugated
200µl  $425.00
Anti-SYN1 / Synapsin 1 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:75.
Western blot of lysates from SH-SY5Y cell line, mouse brain, rat brain, rat cerebellum tissue (from left to right), using SYN1 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
Anti-SYN1 / Synapsin 1 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:75.
Western blot of lysates from SH-SY5Y cell line, mouse brain, rat brain, rat cerebellum tissue (from left to right), using SYN1 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.

SYN1 / Synapsin 1 Antibody (phospho-Ser9) LS-C178056
Rabbit Polyclonal to Human SYN1 / Synapsin 1
Mouse, Rat, Human
IF IHC IHC-P WB
Unconjugated
100µl  $345.00
IHC of p-Synapsin I (S9) pAb in paraffin-embedded human brain tissue.
Western blot of p-Synapsin I (S9) pAb in extracts from A549 cells.
IHC of p-Synapsin I (S9) pAb in paraffin-embedded human brain tissue.
Western blot of p-Synapsin I (S9) pAb in extracts from A549 cells.

SYN1 / Synapsin 1 Antibody (Tyr3) LS-C177708
Rabbit Polyclonal to Human SYN1 / Synapsin 1
Mouse, Rat, Human
IF IHC IHC-P WB
Unconjugated
100µl  $345.00
IHC of Synapsin I (Y3) pAb in paraffin-embedded human brain tissue.
Western blot of Synapsin I (Y3) pAb in extracts from HeLa cells.
IHC of Synapsin I (Y3) pAb in paraffin-embedded human brain tissue.
Western blot of Synapsin I (Y3) pAb in extracts from HeLa cells.

SYN1 / Synapsin 1 Antibody LS-C56990
Rabbit Polyclonal to Bovine SYN1 / Synapsin 1
Mouse, Bovine, Rat, Human
IF IHC IHC-Fr IP WB
Unconjugated
10µg 50µl  $635.00

SYN1 / Synapsin 1 Antibody (550-630 aa) LS-C381743
Rabbit Polyclonal (IgG) to Human SYN1 / Synapsin 1
Mouse, Rat, Human
ELISA IF IHC
Unconjugated
100µl 1mg/ml  $265.00

SYN1 / Synapsin 1 Antibody (550-630 aa) LS-C386248
Rabbit Polyclonal (IgG) to Human SYN1 / Synapsin 1
Mouse, Rat, Human
ELISA IF IHC
Unconjugated
100µl 1mg/ml  $265.00

SYN1 / Synapsin 1 Antibody LS-C39351
Rabbit Polyclonal (IgG) to Bovine SYN1 / Synapsin 1
Bovine, Rat, Human
ELISA ICC IP WB
Unconjugated
50µl  $665.00

SYN1 / Synapsin 1 Antibody LS-C403245
Rabbit Polyclonal (IgG) to Human SYN1 / Synapsin 1
Mouse, Human
ELISA IHC WB
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human tonsil using SYN1 Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of Human thyroid cancer using SYN1 Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of Human tonsil using SYN1 Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of Human thyroid cancer using SYN1 Polyclonal Antibody at dilution of 1:40.

SYN1 / Synapsin 1 Antibody LS-C406481
Rabbit Polyclonal (IgG) to Human SYN1 / Synapsin 1
Human
ELISA IHC WB
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human liver cancer using SYN1 Polyclonal Antibody at dilution of 1:50.
Immunohistochemistry of Human colon cancer using SYN1 Polyclonal Antibody at dilution of 1:50.
Immunohistochemistry of Human liver cancer using SYN1 Polyclonal Antibody at dilution of 1:50.
Immunohistochemistry of Human colon cancer using SYN1 Polyclonal Antibody at dilution of 1:50.

SYN1 / Synapsin 1 Antibody (clone 7B1D9) LS-C669469
Mouse Monoclonal [clone 7B1D9] (IgG1) to Human SYN1 / Synapsin 1
Human
ELISA IF WB
Unconjugated
0.1mg  $365.00

SYN1 / Synapsin 1 Antibody (aa26-75) LS-C117716
Rabbit Polyclonal (IgG) to Human SYN1 / Synapsin 1
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Synapsin1 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from NIH/3T3 cells, treated with Nocodazole 1ug/ml 16h, using Synapsin1 Antibody. The lane on the right is blocked with the synthesized peptide.
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Synapsin1 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from NIH/3T3 cells, treated with Nocodazole 1ug/ml 16h, using Synapsin1 Antibody. The lane on the right is blocked with the synthesized peptide.

SYN1 / Synapsin 1 Antibody (phospho-Ser62) LS-C199626
Rabbit Polyclonal (IgG) to Human SYN1 / Synapsin 1
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human brain, using Synapsin1 (Phospho-Ser62) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of lysates from HeLa cells treated with Anisomycin 25ug/ml 30', using Synapsin1 (Phospho-Ser62) Antibody. The lane on the right is blocked with the phospho peptide.
Immunohistochemistry analysis of paraffin-embedded human brain, using Synapsin1 (Phospho-Ser62) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of lysates from HeLa cells treated with Anisomycin 25ug/ml 30', using Synapsin1 (Phospho-Ser62) Antibody. The lane on the right is blocked with the phospho peptide.
Showing 1-25 of 81 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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