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Unfortunately, the antibody (ID:27427) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



SYK

spleen tyrosine kinase

Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade. Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen.

Gene Name: spleen tyrosine kinase
Family/Subfamily: Protein Kinase , Syk/ZAP70
Synonyms: SYK, p72syk, Spleen tyrosine kinase, Syk protein-tyrosine kinase, Tyrosine-protein kinase SYK, p72-Syk
Target Sequences: NM_003177 NP_003168.2 P43405

Publications (1)

1
Cutting edge: critical role of intracellular osteopontin in antifungal innate immune responses. Inoue M, Moriwaki Y, Arikawa T, Chen YH, Oh YJ, Oliver T, Shinohara ML. Journal of immunology (Baltimore, Md. : 1950). 2011 186:19-23. [PubMed:21135164] [PMC:PMC3538145] Related Antibodies: LS-B1652.

Filtered By: None
Target
syk (129)
Reactivity
Human (124)
Mouse (55)
Rat (46)
Bat (1)
Bovine (6)
Chicken (1)
Dog (7)
Guinea pig (1)
Horse (6)
Monkey (8)
Pig (7)
Rabbit (7)
Application
IHC (37)
IHC-P (30)
WB (111)
Flo (1)
ELISA (60)
ICC (7)
IF (14)
Inhb (1)
IP (29)
Host
rabbit (99)
mouse (29)
goat (1)
Isotype
IgG (67)
IgG1 (12)
IgG1,k (2)
IgG2a,k (12)
IgG2b (1)
IgG2b,k (1)
IgM,k (1)
Clonality
monoclonal mc (29)
polyclonal pc (100)
Clone
0.N.559 (1)
11J26 (1)
12E3 (1)
1D4B (1)
4A7 (1)
4D10.1 (3)
8C1A3 (1)
8H5 (1)
SYK-01 (4)
Format
AP Conjugated (6)
APC Conjugated (5)
Azide-free (4)
Biotin Conjugated (10)
FITC Conjugated (9)
HRP Conjugated (7)
PE Conjugated (6)
Unconjugated (86)
Epitope
pTyr323 (13)
aa195-223 (7)
aa268-305 (7)
Tyr525/526 (6)
aa5-360 (6)
aa292-341 (4)
pTyr348 (4)
aa313-339 (3)
aa340-607 (3)
aa374-635 (3)
pTyr352 (3)
pTyr525 (3)
C-Terminus (2)
Pro342 (2)
Tyr323 (2)
aa250-300 (2)
aa290-370 (2)
aa313-330 (2)
pTyr525/526 (2)
pTyr525/Tyr526 (2)
Internal (1)
Leu519 (1)
Phe169 (1)
Tyr525/Tyr526 (1)
aa110-190 (1)
aa141-190 (1)
aa194-223 (1)
aa260-340 (1)
aa289-338 (1)
aa306-333 (1)
aa31-59 (1)
aa314-339 (1)
aa314-363 (1)
aa318-352 (1)
aa321-325 (1)
aa350-400 (1)
aa458-470 (1)
aa460-540 (1)
aa491-540 (1)
aa516-549 (1)
Publications
No (128)
Yes (1)
Showing 1-25 out of 129 results
Anti-SYK Antibody (aa5-360) IHC-plus™ LS-B2240

Mouse Monoclonal (IgG1) to Human SYK
Mouse, Rat, Human
ICC IHC-P IP WB
Unconjugated
Anti-SYK Antibody (aa5-360, clone SYK-01) IHC-plus™ LS-B1652

Mouse Monoclonal [clone SYK-01] (IgG1) to Human SYK
Mouse, Rat, Human
IHC-P WB
Unconjugated
Anti-SYK Antibody (aa313-330, clone 12E3) IHC-plus™ LS-B7089

Mouse Monoclonal [clone 12E3] (IgG2b,k) to Human SYK
Human
IHC-P IP WB
Unconjugated
Anti-SYK Antibody (aa313-339) IHC-plus™ LS-B5293

Rabbit Polyclonal (IgG) to Human SYK
Human
IHC-P IP WB
Unconjugated
Anti-SYK Antibody (aa5-360, clone SYK-01) IHC-plus™ LS-B1877

Mouse Monoclonal [clone SYK-01] (IgG1) to Human SYK
Mouse, Rat, Human
ICC IHC-P Inhb IP WB
Unconjugated
Anti-SYK Antibody (aa314-339, clone 1D4B) LS-C189758

Mouse Monoclonal [clone 1D4B] (IgG2a,k) to Human SYK
Human
Flo IP WB
Unconjugated
Anti-SYK Antibody (clone 4D10.1, Biotin) LS-C88077

Mouse Monoclonal [clone 4D10.1] (IgG2a,k) to Human SYK
Human
IHC-P IP WB
Biotin Conjugated
Anti-SYK Antibody (aa250-300) IHC-plus™ LS-B11824

Rabbit Polyclonal (IgG) to Human SYK
Human
IF IHC-P IP
Unconjugated
Anti-SYK Antibody (aa5-360) IHC-plus™ LS-B11825

Mouse Monoclonal (IgG1) to Human SYK
Mouse, Rat, Human
IHC-P IP WB
Unconjugated
Anti-SYK Antibody (aa289-338) LS-C117715

Rabbit Polyclonal (IgG) to Human SYK
Mouse, Rat, Human
ELISA IF IHC-P
Unconjugated
Anti-SYK Antibody (clone 4D10.1, Azide-free) LS-C88078

Mouse Monoclonal [clone 4D10.1] (IgG2a,k) to Human SYK
Human
IHC-P IP WB
Unconjugated, Azide-free
Anti-SYK Antibody (aa314-363) LS-C117582

Rabbit Polyclonal (IgG) to Human SYK
Mouse, Rat, Human
ELISA IHC-P WB
Unconjugated
Anti-SYK Antibody (aa491-540) LS-C117583

Rabbit Polyclonal (IgG) to Human SYK
Mouse, Rat, Human
ELISA IHC-P WB
Unconjugated
Anti-SYK Antibody (aa313-339, clone 0.N.559) LS-C10480

Mouse Monoclonal [clone 0.N.559] (IgG2a,k) to Human SYK
Human
IP WB
Unconjugated
Anti-SYK Antibody (phospho-Tyr348) LS-C352922

Rabbit Polyclonal to Human SYK
Chicken, Rabbit, Mouse, Dog, Rat, Pig, Human
IHC-P IP WB
Unconjugated
Anti-SYK Antibody (aa350-400) LS-C287444

Rabbit Polyclonal (IgG) to Human SYK
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Horse, Human
IP WB
Unconjugated
Anti-SYK Antibody (aa313-330, clone 8H5) IHC-plus™ LS-B7088

Mouse Monoclonal [clone 8H5] (IgG1,k) to Human SYK
Human
ELISA IHC-P IP
Unconjugated
Anti-SYK Antibody (phospho-Tyr323) LS-C416379

Rabbit Polyclonal to Human SYK
Mouse, Rat, Human
ICC IF IHC WB
Unconjugated
Anti-SYK Antibody (phospho-Tyr323) LS-C381493

Rabbit Polyclonal (IgG) to Human SYK
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
Anti-SYK Antibody (phospho-Tyr323) LS-C352910

Rabbit Polyclonal to Human SYK
Mouse, Rat, Human
ICC IF IHC-P WB
Unconjugated
Anti-SYK Antibody (phospho-Tyr323) LS-C199622

Rabbit Polyclonal (IgG) to Human SYK
Mouse, Rat, Human
ELISA IF IHC-P WB
Unconjugated
Anti-SYK Antibody (phospho-Tyr323) LS-C335942

Rabbit Polyclonal (IgG) to Human SYK
Human
IF IHC WB
Unconjugated
Anti-SYK Antibody LS-C416917

Rabbit Polyclonal to Human SYK
Mouse, Rat, Human
ICC IF IHC
Unconjugated
Anti-SYK Antibody (aa260-340) LS-C386258

Rabbit Polyclonal (IgG) to Human SYK
Mouse, Rat, Human
ELISA IF IHC
Unconjugated
Anti-SYK Antibody LS-C331917

Rabbit Polyclonal (IgG) to Human SYK
Mouse, Rat, Human
IHC WB
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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