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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SUV39H1

suppressor of variegation 3-9 homolog 1 (Drosophila)

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.

Gene Name: suppressor of variegation 3-9 homolog 1 (Drosophila)
Synonyms: SUV39H1, H3-K9-HMTase 1, MG44, KMT1A, Lysine N-methyltransferase 1A, Su(var)3-9 homolog 1, SUV39H
Target Sequences: NM_003173 NP_003164.1 O43463

Publications (1)

1
Activation of Hif1 by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity. Ayrapetov MK, Xu C, Sun Y, Zhu K, Parmar K, D'Andrea AD, Price BD. PloS one. 2011 6:e26064. [PubMed:22016813] [PMC:PMC3189247]

Filtered By: None
Target
SUV39H1 (57)
Reactivity
Human (56)
Mouse (34)
Rat (11)
Bovine (10)
Chimpanzee (6)
Dog (10)
Gibbon (6)
Guinea pig (9)
Hamster (9)
Horse (5)
Monkey (8)
Orangutan (6)
Pig (1)
Rabbit (9)
Zebrafish (4)
Application
IHC (11)
IHC-P (5)
WB (52)
ELISA (27)
IP (11)
Host
rabbit (46)
mouse (11)
Isotype
IgG (41)
IgG1 (9)
Clonality
monoclonal mc (10)
polyclonal pc (47)
Format
AP Conjugated (5)
APC Conjugated (5)
Azide-free (3)
Biotin Conjugated (9)
FITC Conjugated (8)
HRP Conjugated (8)
PE Conjugated (5)
Unconjugated (17)
Epitope
N-Terminus (8)
aa79-108 (8)
C-Terminus (4)
aa108-157 (4)
aa1-412 (1)
aa25-75 (1)
aa368-392 (1)
aa42-100 (1)
aa82-415 (1)
Publications
No (57)
Showing 1-25 of 57 results

SUV39H1 Antibody (N-Terminus) LS-C68008
Mouse Monoclonal (IgG1) to Human SUV39H1
Mouse, Human
ELISA IP WB
Unconjugated
50µl 2mg/ml  $515.00

SUV39H1 Antibody LS-C679702
Rabbit Polyclonal (IgG) to Human SUV39H1
Human
ELISA IHC IHC-P
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human breast cancer at dilution of 1:100
Immunohistochemistry of paraffin-embedded human tonsil tissue at dilution of 1:100
Immunohistochemistry of paraffin-embedded human breast cancer at dilution of 1:100
Immunohistochemistry of paraffin-embedded human tonsil tissue at dilution of 1:100

SUV39H1 Antibody LS-C328812
Rabbit Polyclonal (IgG) to Human SUV39H1
Mouse, Human
ELISA WB
Unconjugated
200µl  $530.00

SUV39H1 Antibody (Biotin) LS-C283256
Rabbit Polyclonal (IgG) to Human SUV39H1
Mouse, Human
ELISA IHC WB
Biotin Conjugated
200µl  $680.00

SUV39H1 Antibody (FITC) LS-C283255
Rabbit Polyclonal (IgG) to Human SUV39H1
Mouse, Human
ELISA IHC WB
FITC Conjugated
200µl  $680.00

SUV39H1 Antibody (PE) LS-C283258
Rabbit Polyclonal (IgG) to Human SUV39H1
Mouse, Human
ELISA IHC WB
PE Conjugated
200µl  $680.00

SUV39H1 Antibody (AP) LS-C283254
Rabbit Polyclonal (IgG) to Human SUV39H1
Mouse, Human
ELISA IHC WB
AP Conjugated
200µl  $680.00

SUV39H1 Antibody (Azide-free, HRP) LS-C283257
Rabbit Polyclonal (IgG) to Human SUV39H1
Mouse, Human
ELISA IHC WB
HRP Conjugated, Azide-free
200µl  $680.00

SUV39H1 Antibody (APC) LS-C283253
Rabbit Polyclonal (IgG) to Human SUV39H1
Mouse, Human
ELISA IHC WB
APC Conjugated
200µl  $680.00

SUV39H1 Antibody (C-Terminus) LS-C30987
Rabbit Polyclonal (IgG) to Human SUV39H1
Zebrafish, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Bovine, Human, Monkey
IHC IHC-P WB
Unconjugated
100µg  $325.00
SUV39H1 antibody ARP32470_T100-NP_003164-SUV39H1 (suppressor of variegation 3-9 homolog 1 (Drosophila)) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HepG2 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SUV39H1 antibody ARP32470_T100-NP_003164-SUV39H1 (suppressor of variegation 3-9 homolog 1 (Drosophila)) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HepG2 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SUV39H1 Antibody (C-Terminus, HRP) LS-C427960
Rabbit Polyclonal (IgG) to Human SUV39H1
Zebrafish, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Human, Monkey, Chimpanzee, Orangutan, Gibbon
IHC IHC-P WB
HRP Conjugated
100µl 0.65mg/ml  $335.00
SUV39H1 antibody ARP32470_T100-NP_003164-SUV39H1 (suppressor of variegation 3-9 homolog 1 (Drosophila)) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HepG2 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SUV39H1 antibody ARP32470_T100-NP_003164-SUV39H1 (suppressor of variegation 3-9 homolog 1 (Drosophila)) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HepG2 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SUV39H1 Antibody (C-Terminus, Biotin) LS-C427958
Rabbit Polyclonal (IgG) to Human SUV39H1
Zebrafish, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Human, Monkey, Chimpanzee, Orangutan, Gibbon
IHC IHC-P WB
Biotin Conjugated
100µl 1mg/ml  $335.00
SUV39H1 antibody ARP32470_T100-NP_003164-SUV39H1 (suppressor of variegation 3-9 homolog 1 (Drosophila)) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HepG2 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SUV39H1 antibody ARP32470_T100-NP_003164-SUV39H1 (suppressor of variegation 3-9 homolog 1 (Drosophila)) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HepG2 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SUV39H1 Antibody (C-Terminus, FITC) LS-C427959
Rabbit Polyclonal (IgG) to Human SUV39H1
Zebrafish, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Human, Monkey, Chimpanzee, Orangutan, Gibbon
IHC IHC-P WB
FITC Conjugated
100µl 1mg/ml  $335.00
SUV39H1 antibody ARP32470_T100-NP_003164-SUV39H1 (suppressor of variegation 3-9 homolog 1 (Drosophila)) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HepG2 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SUV39H1 antibody ARP32470_T100-NP_003164-SUV39H1 (suppressor of variegation 3-9 homolog 1 (Drosophila)) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HepG2 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SUV39H1 Antibody LS-C753136
Rabbit Polyclonal (IgG) to Human SUV39H1
Human
ELISA IP WB
Unconjugated
100µg  $355.00

SUV39H1 Antibody (N-Terminus) LS-C132319
Mouse Monoclonal (IgG1) to Human SUV39H1
ELISA WB
Unconjugated
200µl  $530.00

SUV39H1 Antibody (N-Terminus, Biotin) LS-C283248
Mouse Monoclonal (IgG1) to Human SUV39H1
Mouse, Human
ELISA WB
Biotin Conjugated
200µl  $680.00

SUV39H1 Antibody (N-Terminus, FITC) LS-C283251
Mouse Monoclonal (IgG1) to Human SUV39H1
Mouse, Human
ELISA WB
FITC Conjugated
200µl  $680.00

SUV39H1 Antibody (N-Terminus, APC) LS-C283249
Mouse Monoclonal (IgG1) to Human SUV39H1
Mouse, Human
ELISA WB
APC Conjugated
200µl  $680.00

SUV39H1 Antibody (N-Terminus, PE) LS-C283250
Mouse Monoclonal (IgG1) to Human SUV39H1
Mouse, Human
ELISA WB
PE Conjugated
200µl  $680.00

SUV39H1 Antibody (N-Terminus, Azide-free, HRP) LS-C283252
Mouse Monoclonal (IgG1) to Human SUV39H1
Mouse, Human
ELISA WB
HRP Conjugated, Azide-free
200µl  $680.00

SUV39H1 Antibody (N-Terminus, AP) LS-C283247
Mouse Monoclonal (IgG1) to Human SUV39H1
Mouse, Human
ELISA WB
AP Conjugated
200µl  $680.00

SUV39H1 Antibody (aa79-108) LS-C325509
Rabbit Polyclonal (IgG) to Human SUV39H1
Human
ELISA WB
Unconjugated
200µl  $530.00

SUV39H1 Antibody (aa79-108, AP) LS-C270757
Rabbit Polyclonal (IgG) to Human SUV39H1
Human
ELISA WB
AP Conjugated
200µl  $680.00

SUV39H1 Antibody (aa25-75) LS-C288885
Rabbit Polyclonal (IgG) to Human SUV39H1
Rabbit, Dog, Guinea pig, Bovine, Pig, Horse, Human
IP WB
Unconjugated
100µl 0.2mg/ml  $395.00

SUV39H1 Antibody (aa82-415) LS-C126340
Rabbit Polyclonal (IgG) to Human SUV39H1
Human
IP WB
Unconjugated
100µg  $695.00
Showing 1-25 of 57 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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