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SURF4 is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants.
Gene Name: | surfeit 4 |
Synonyms: | SURF4, ERV29, Surfeit 4, Surfeit locus protein 4, SURF-4 |
Target Sequences: | NM_033161 NP_149351.1 O15260 |
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