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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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SUMO4
small ubiquitin-like modifier 4
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.
| Gene Name: | small ubiquitin-like modifier 4 |
| Synonyms: | SUMO4, DJ281H8.4, IDDM5, Small ubiquitin-like protein 4, SMT3H4, SUMO-4 |
| Target Sequences: | NP_001002255.1 Q6EEV6 |
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