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SUMO3
small ubiquitin-like modifier 3
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.
| Gene Name: | small ubiquitin-like modifier 3 |
| Synonyms: | SUMO3, SMT3A, SMT3 homolog 1, Smt3B, SMT3H1, SUMO-2, SUMO-3, Ubiquitin-like protein SMT3A, Ubiquitin-like protein SMT3B |
| Target Sequences: | NM_006936 NP_008867.2 P55854 |
Publications (1)
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