STUB1 / CHIP

STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

STUB1 / CHIP (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (3)

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Human STUB1 / CHIP Protein (Recombinant) (Met1-Tyr303) - LS-G38653

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

34.86kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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STUB1 / CHIP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115694

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.7 kDa

Price:

100 µg/$494

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Human STUB1 / CHIP Protein (Recombinant) - LS-G3368

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

100 µg/$317; 500 µg/$526; 20 µg/$245

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Human STUB1 / CHIP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71297

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.7 kDa

Price:

20 µg/$1,107

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Human STUB1 / CHIP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89437

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.7 kDa

Price:

20 µg/$150

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Human STUB1 / CHIP Protein (Recombinant GST, N-terminus) (aa204-303) - LS-G61449

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human STUB1 / CHIP Protein (Recombinant) (Met1-Tyr303) - LS-G139565

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

34.9 kDa

Price:

10 µg/$376; 50 µg/$526

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Human STUB1 / CHIP Protein (Recombinant GST) (Full Length) - LS-G32061

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

61.3 kDa

Price:

10 µg/$479; 25 µg/$670

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