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Metalloreductase that has the ability to reduce both Fe3+ to Fe2+ and Cu2+ to Cu1+. Uses NAD+ as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation.
Gene Name: | STEAP family member 4 |
Synonyms: | STEAP4, STEAP family member 4, Metalloreductase STEAP4, STAMP2, TIARP, TNFAIP9 |
Target Sequences: | NM_024636 NP_078912.2 Q687X5 |
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