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STAT2

signal transducer and activator of transcription 2, 113kDa

STAT2 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: signal transducer and activator of transcription 2, 113kDa
Synonyms: STAT2, ISGF-3, STAT113, p113
Target Sequences: NM_005419 NP_005410.1 P52630

Publications (2)

1
STAT2-dependent induction of RNA adenosine deaminase ADAR1 by type I interferon differs between mouse and human cells in the requirement for STAT1. George CX, Samuel CE. Virology. 2015 November;485:363-70. (Mouse) [Full Text Article] [PubMed:26335850] [PMC:PMC4619148]
2
The Transcription Factor T-bet Limits Amplification of Type I IFN Transcriptome and Circuitry in T Helper 1 Cells. Iwata S, Mikami Y, Sun HW, Brooks SR, Jankovic D, Hirahara K, Onodera A, Shih HY, Kawabe T, Jiang K, Nakayama T, Sher A, O'Shea JJ, Davis FP, Kanno Y. Immunity. 2017 June;46:983-991. (Mouse) [Full Text Article] [PubMed:28623086] [PMC:PMC5523825] Related Antibodies: LS-C10379.

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Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
STAT2 (7)
No (7)
GST, N-terminus (1)
His-T7 (3)
Myc-DDK (Flag) (3)
Human (4)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (3)
HEK 293 Cells (2)
Wheat Germ Extract (1)
STAT2 Protein - Purified recombinant protein STAT2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
97.7 kDa
20 µg/$1,107
STAT2 Protein - Recombinant Signal Transducer And Activator Of Transcription 2 By SDS-PAGE
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E. coli
His-T7
30.7 kDa
10 µg/$277; 50 µg/$420; 100 µg/$670; 200 µg/$837; 1 mg/$1,928; 500 µg/$1,474; 5 mg/$2,927; 2 mg/$2,113
STAT2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
97.7 kDa
100 µg/$494
STAT2 Protein - Recombinant  Signal Transducer And Activator Of Transcription 2 By SDS-PAGE
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E. coli
His-T7
32.6 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
STAT2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
STAT2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
97.7 kDa
20 µg/$150
STAT2 Protein - Recombinant Signal Transducer And Activator Of Transcription 2 By SDS-PAGE
Select
E. coli
His-T7
32.2 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).