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SSH1 belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene Name: | slingshot protein phosphatase 1 |
Family/Subfamily: | Protein Phosphatase , Slingshot |
Synonyms: | SSH1, SSH-like protein 1, HSSH-1L, KIAA1298, Slingshot 1, SSH1L |
Target Sequences: | NM_018984 NP_061857.3 Q8WYL5 |
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