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SRSF2 / SC35

serine/arginine-rich splicing factor 2

Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.

Gene Name: serine/arginine-rich splicing factor 2
Synonyms: SRSF2, PR264, Protein PR264, SFRS2, Splicing component, 35 kDa, Splicing factor sc35, SR splicing factor 2, SRp30b, SC35, SC-35, SFRS2A
Target Sequences: NM_003016 NP_003007.2 Q01130

Publications (1)

1
Regulation of Mcl-1 by SRSF1 and SRSF5 in cancer cells. Gautrey HL, Tyson-Capper AJ. PloS one. 2012 7:e51497. [PubMed:23284704] [PMC:PMC3524227] Related Antibodies: LS-C97287.

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
SRSF2 / SC35 (4)
No (4)
GST (1)
His-GST (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
SRSF2 / SC35 Protein - Recombinant  Serine/Arginine Rich Splicing Factor 2 By SDS-PAGE
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E. coli
His-GST
54.1 kDa
10 µg/$279; 50 µg/$430; 100 µg/$687; 200 µg/$857; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142
SRSF2 / SC35 Protein - 12.5% SDS-PAGE of human SFRS2 stained with Coomassie Blue
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Wheat Germ Extract
GST
45.43 kDa
10 µg/$479; 25 µg/$670
SRSF2 / SC35 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
25.3 kDa
100 µg/$494
SRSF2 / SC35 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
25.3 kDa
20 µg/$150
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).