SRPK2

SRSF protein kinase 2

Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.

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Products

Proteins (11)

Type

Over-Expression Lysate (4)

Recombinant (7)

Target

SRPK2 (11)

Publications

No (11)

Tag

GST (4)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (5)

Species

Human (9)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (5)

Purification

Purified (4)

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Human SRPK2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68315

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.3 kDa

Price:

20 µg/$1,107

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SRPK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104175

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

78.8 kDa

Price:

100 µg/$710

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SRPK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102525

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.3 kDa

Price:

100 µg/$494

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Human SRPK2 Protein (Recombinant His-T7) (aa380-617) - LS-G25845

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.1 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human SRPK2 Protein (Recombinant GST, N-terminus) (aa589-688) - LS-G60209

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SRPK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81913

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.3 kDa

Price:

20 µg/$150

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Human SRPK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81914

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

78.8 kDa

Price:

20 µg/$215

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Human SRPK2 Protein (Recombinant GST) (Full Length) - LS-G30534

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

101.42 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SRPK2 Protein (Recombinant GST) (Full Length) - LS-G30536

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

101.31 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SRPK2 Protein (Recombinant GST) (Full Length) - LS-G30537

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

105.4 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SRPK2 Protein (Recombinant GST) (Full Length) - LS-G30538

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

103.73 kDa

Price:

10 µg/$479; 25 µg/$670

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