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GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
Gene Name: | SLIT-ROBO Rho GTPase activating protein 1 |
Synonyms: | SRGAP1, ARHGAP13, KIAA1304 |
Target Sequences: | NM_020762 NP_065813.1 Q7Z6B7 |
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