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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SREBF1 / SREBP-1

sterol regulatory element binding transcription factor 1

SREBF1 / SREBP-1 is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: sterol regulatory element binding transcription factor 1
Synonyms: SREBF1, BHLHd1, SREBP-1, SREBP-1c, SREBP1
Target Sequences: NM_004176 NP_004167.3 P36956

Publications (13)

1
Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Sheng Z, Otani H, Brown MS, Goldstein JL. Proceedings of the National Academy of Sciences of the United States of America. 1995 92:935-8. [PubMed:7862668] [PMC:PMC42611]
2
Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1). Sato R, Yang J, Wang X, Evans MJ, Ho YK, Goldstein JL, Brown MS. The Journal of biological chemistry. 1994 269:17267-73. [PubMed:8006035]
3
Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. Shimano H, Shimomura I, Hammer RE, Herz J, Goldstein JL, Brown MS, Horton JD. The Journal of clinical investigation. 1997 100:2115-24. [PubMed:9329978] [PMC:PMC508404]
4
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Yabe D, Brown MS, Goldstein JL. Proceedings of the National Academy of Sciences of the United States of America. 2002 99:12753-8. [PubMed:12242332] [PMC:PMC130532]
5
Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism. Kim HJ, Miyazaki M, Ntambi JM. Journal of lipid research. 2002 43:1750-7. [PubMed:12364560]
6
Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues. Gosmain Y, Dif N, Berbe V, Loizon E, Rieusset J, Vidal H, Lefai E. Journal of lipid research. 2005 46:697-705. [PubMed:15627654]
7
Activated sterol regulatory element-binding protein-2 suppresses hepatocyte nuclear factor-4-mediated Cyp3a11 expression in mouse liver. Inoue S, Yoshinari K, Sugawara M, Yamazoe Y. Molecular pharmacology. 2011 79:148-56. [PubMed:20926756]
8
Species-specific dibutyl phthalate fetal testis endocrine disruption correlates with inhibition of SREBP2-dependent gene expression pathways. Johnson KJ, McDowell EN, Viereck MP, Xia JQ. Toxicological sciences : an official journal of the Society of Toxicology. 2011 120:460-74. (WB; Rat) [PubMed:21266533] [PMC:PMC3061485]
9
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Herman MA, Peroni OD, Villoria J, Schn MR, Abumrad NA, Blher M, Klein S, Kahn BB. Nature. 2012 484:333-8. (WB; Mouse) [PubMed:22466288] [PMC:PMC3341994]
10
Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice. Yang A, Gyulay G, Mitchell M, White E, Trigatti BL, Igdoura SA. Journal of lipid research. 2012 53:2573-85. [PubMed:22984145] [PMC:PMC3494259]
11
The Niemann-Pick C1 gene is downregulated in livers of C57BL/6J mice by dietary fatty acids, but not dietary cholesterol, through feedback inhibition of the SREBP pathway. Jelinek D, Castillo JJ, Richardson LM, Luo L, Heidenreich RA, Garver WS. The Journal of nutrition. 2012 142:1935-42. (WB; Mouse) [PubMed:22990467] [PMC:PMC3497932]
12
Hepatic Peroxisome Proliferator-Activated Receptor Gamma Signaling Contributes to Alcohol-Induced Hepatic Steatosis and Inflammation in Mice. Zhang W, Sun Q, Zhong W, Sun X, Zhou Z. Alcoholism, clinical and experimental research. 2016 May;40:988-99. (Human) [Full Text Article] [PubMed:27062444] [PMC:PMC5742869] Related Antibodies: LS-B93.
13
Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal. Schmitt J, Kong B, Stieger B, Tschopp O, Schultze SM, Rau M, Weber A, M[Character fc]llhaupt B, Guo GL, Geier A. Liver international : official journal of the International Association for the Study of the Liver. Apr;35:1133-44. [Full Text Article] [PubMed:25156247] [PMC:PMC4146754] Related Antibodies: LS-C30185.
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Viewing 1-25 of 83 items
SREBF1 / SREBP-1 Antibody - Anti-SREBF1 / SREBP-1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
(1) Publication(s)
Rabbit Polyclonal to Human SREBF1 / SREBP-1
Mouse, Goat, Sheep, Bovine, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $425.00
SREBF1 / SREBP-1 Antibody - Anti-SREBF1 / SREBP-1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human SREBF1 / SREBP-1
Mouse, Bovine, Rat, Pig, Plant, Human
IHC, IHC-P, WB
Biotin Conjugated
100µl   $365.00
SREBF1 / SREBP-1 Antibody - Anti-SREBF1 / SREBP-1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human SREBF1 / SREBP-1
Mouse, Rat, Pig, Human
IHC, IHC-P, WB
DY650 Conjugated
100µl   $365.00
SREBF1 / SREBP-1 Antibody - Anti-SREBF1 / SREBP-1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human SREBF1 / SREBP-1
Goat, Bovine, Rat, Hamster, Horse, Human
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
SREBF1 / SREBP-1 Antibody - Anti-SREBF1 / SREBP-1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human SREBF1 / SREBP-1
Goat, Bovine, Rat, Hamster, Horse, Chimpanzee, Human
IHC, IHC-P, WB
HRP Conjugated
100µl   0.65mg/ml   $385.00
SREBF1 / SREBP-1 Antibody - Anti-SREBF1 / SREBP-1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human SREBF1 / SREBP-1
Goat, Bovine, Rat, Hamster, Horse, Chimpanzee, Human
IHC, IHC-P, WB
Biotin Conjugated
100µl   1mg/ml   $385.00
SREBF1 / SREBP-1 Antibody - Anti-SREBF1 / SREBP-1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human SREBF1 / SREBP-1
Goat, Bovine, Rat, Hamster, Horse, Chimpanzee, Human
IHC, IHC-P, WB
FITC Conjugated
100µl   1mg/ml   $385.00
SREBF1 / SREBP-1 Antibody - SP2/0 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
(1) Publication(s)
Rabbit Polyclonal (IgG) to Mouse SREBF1 / SREBP-1
Mouse
WB
Unconjugated
100µl   0.5mg/ml   $365.00
SREBF1 / SREBP-1 Antibody - Immunohistochemical analysis of SREBP1 (pS439) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Rabbit Polyclonal to Human SREBF1 / SREBP-1
Mouse, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
30µl   1mg/ml   $215.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $325.00
Select
Rabbit Polyclonal (IgG) to Rat SREBF1 / SREBP-1
Mouse, Rat, Human
WB
Unconjugated
30µg   $245.00; 100µg   $385.00
SREBF1 / SREBP-1 Antibody - Immunohistochemistry of SREBF1 in human spleen tissue with SREBF1 antibody at 5 ug/mL.
Select
Rabbit Polyclonal (IgG) to Human SREBF1 / SREBP-1
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
0.1mg   1mg/ml   $365.00
SREBF1 / SREBP-1 Antibody - Formalin-fixed and paraffin-embedded human breast carcinoma reacted with SREBF1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Rabbit Polyclonal to Human SREBF1 / SREBP-1
Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
SREBF1 / SREBP-1 Antibody
Select
Rabbit Polyclonal (IgG) to Human SREBF1 / SREBP-1
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Mouse Monoclonal [clone 2A4] (IgG1,k) to Human SREBF1 / SREBP-1
Hamster, Human
WB
Unconjugated
100µl   200µg/ml   $295.00; 500µl   200µg/ml   $620.00; 1ml   200µg/ml   $935.00
SREBF1 / SREBP-1 Antibody - SREBP1 Antibody (2A4) - Western blot of SREBP1 expression in HeLa lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 2A4] (IgG1,k) to Human SREBF1 / SREBP-1
Mouse, Rat, Hamster, Human
WB
Unconjugated
100µl   1mg/ml   $335.00
SREBF1 / SREBP-1 Antibody - SREBP1 Antibody (2A4) - Western blot of SREBP1 expression in HeLa lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 2A4] (IgG1,k) to Human SREBF1 / SREBP-1
Mouse, Rat, Hamster, Human
WB
DY550 Conjugated
100µl   1mg/ml   $365.00
SREBF1 / SREBP-1 Antibody
Select
Rabbit Polyclonal (IgG) to Human SREBF1 / SREBP-1
Mouse, Sheep, Rat, Pig, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
SREBF1 / SREBP-1 Antibody - IF using SREBP1 Antibody
Select
Rabbit Polyclonal (IgG) to Human SREBF1 / SREBP-1
Mouse, Goat, Dog, Guinea pig, Rat, Hamster, Pig, Gibbon, Chimpanzee, Human, Monkey
ICC, IF, WB
Unconjugated
100µg   $445.00
SREBF1 / SREBP-1 Antibody - Immunohistochemistry image at a dilution of 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Select
Rabbit Polyclonal (IgG) to Human SREBF1 / SREBP-1
Human
ELISA, IHC, IHC-P
Unconjugated
50µg   $285.00; 100µg   $385.00
SREBF1 / SREBP-1 Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using SREBP-1 Antibody. The picture on the right is blocked with the synthesized peptide.
Select
Rabbit Polyclonal (IgG) to Human SREBF1 / SREBP-1
Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
SREBF1 / SREBP-1 Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using SREBP-1 (Phospho-Ser439) Antibody. The picture on the right is blocked with the phospho peptide.
Select
Rabbit Polyclonal (IgG) to Human SREBF1 / SREBP-1
Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
Select
Rabbit Polyclonal (IgG) to Human SREBF1 / SREBP-1
Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
SREBF1 / SREBP-1 Antibody - Western blot of SREBP-1 antibody
Select
Rabbit Polyclonal (IgG) to Human SREBF1 / SREBP-1
Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
SREBF1 / SREBP-1 Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using SREBP-1 (Phospho-Ser439) antibody.
Select
Rabbit Polyclonal (IgG) to Human SREBF1 / SREBP-1
Rat, Human
ELISA, IHC, WB
Unconjugated
100µg   $305.00
SREBF1 / SREBP-1 Antibody - SREBF1 monoclonal antibody (M01), clone 4B10. Western Blot analysis of SREBF1 expression in HeLa.
Select
Mouse Monoclonal [clone 4B10] (IgG2a,k) to Human SREBF1 / SREBP-1
Human
ELISA, WB
Unconjugated
100µg   $365.00

Viewing 1-25 of 83 items


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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).