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SPTLC3 / C20orf38
serine palmitoyltransferase, long chain base subunit 3
The SPTLC3 gene encodes an isoform of the third subunit of serine palmitoyltransferase (SPT; EC 2.3.1.50), which catalyzes the rate-limiting step of the de novo synthesis of sphingolipids (Hornemann et al., 2006 [PubMed 17023427]). SPT contains 2 main subunits: the common SPTLC1 subunit (MIM 605712) and either SPTLC2 (MIM 605713) or its isoform SPTLC2L (SPTLC3), depending on the tissue in which biosynthesis occurs (Hornemann et al., 2006 [PubMed 17023427]). There are also 2 highly related isoforms of a third subunit, SSSPTA (MIM 613540) and SSSPTB (MIM 610412), that confer acyl-CoA preference of the SPT enzyme and are essential for maximal enzyme activity (Han et al., 2009 [PubMed 19416851]).
| Gene Name: | serine palmitoyltransferase, long chain base subunit 3 |
| Synonyms: | SPTLC3, HLCB2b, LCB2B, LCB3, LCB 3, Serine palmitoyltransferase 3, SPT 3, SPT3, C20orf38, DJ718P11, DJ718P11.1, SPTLC2L |
| Target Sequences: | NM_018327 NP_060797.2 Q9NUV7 |
Publications (1)
1
Regulation of the amount of ceramide-1-phosphate synthesized in differentiated human podocytes. Shamroop Kumar Mallela, Alla Mitrofanova, Sandra Merscher, Alessia Fornoni. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2019 December;1864:158517. [Full Text Article]
[PubMed:31487557]
[PMC:PMC6832884]
Related Antibodies: LS-C397341.
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Recombinant
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Target
SPTLC3 / C20orf38
(25)
Reactivity
Human
(22)
Mouse
(13)
Application
WB
(18)
ELISA
(5)
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rabbit
(21)
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Ig
(1)
IgG
(4)
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polyclonal pc
(21)
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96-Well Strip Plate
(2)
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(2)
APC Conjugated
(2)
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(3)
Cy3 Conjugated
(2)
Cy7 Conjugated
(2)
FITC Conjugated
(3)
HRP Conjugated
(3)
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(2)
Unconjugated
(4)
Epitope
aa238-552
(8)
aa80-563
(8)
C-Terminus
(1)
Publications
No
(24)
Yes
(1)
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Cell Lysates
(1)
Tissue Homogenates
(2)
Tag
His-T7
(2)
Species
Human
(1)
Mouse
(1)
Source
E. coli
(2)
SPTLC3 / C20orf38 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
SPTLC3 / C20orf38 Rabbit anti-Human Polyclonal (HRP) Antibody
Mouse, Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
SPTLC3 / C20orf38 Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
SPTLC3 / C20orf38 Rabbit anti-Human Polyclonal (FITC) Antibody
Mouse, Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
SPTLC3 / C20orf38 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$393
SPTLC3 / C20orf38 Rabbit anti-Mouse Polyclonal (aa80-563) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
SPTLC3 / C20orf38 Rabbit anti-Mouse Polyclonal (aa80-563) (HRP) Antibody
Mouse, Human
WB
HRP Conjugated
100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639
SPTLC3 / C20orf38 Rabbit anti-Mouse Polyclonal (aa80-563) (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
SPTLC3 / C20orf38 Rabbit anti-Mouse Polyclonal (aa80-563) (FITC) Antibody
Mouse, Human
WB
FITC Conjugated
100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765
SPTLC3 / C20orf38 Rabbit anti-Mouse Polyclonal (aa80-563) (APC) Antibody
Mouse, Human
WB
APC Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
SPTLC3 / C20orf38 Rabbit anti-Mouse Polyclonal (aa80-563) (PE) Antibody
Mouse, Human
WB
PE Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
SPTLC3 / C20orf38 Rabbit anti-Mouse Polyclonal (aa80-563) (APC, Cy7) Antibody
Mouse, Human
WB
APC, Cy7 Conjugated
100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781
SPTLC3 / C20orf38 Rabbit anti-Mouse Polyclonal (aa80-563) (Cy3) Antibody
Mouse, Human
WB
Cy3 Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
SPTLC3 / C20orf38 Rabbit anti-Human Polyclonal (aa238-552) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
SPTLC3 / C20orf38 Rabbit anti-Human Polyclonal (aa238-552) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593
SPTLC3 / C20orf38 Rabbit anti-Human Polyclonal (aa238-552) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
SPTLC3 / C20orf38 Rabbit anti-Human Polyclonal (aa238-552) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716
SPTLC3 / C20orf38 Rabbit anti-Human Polyclonal (aa238-552) (APC) Antibody
Human
WB
APC Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
SPTLC3 / C20orf38 Rabbit anti-Human Polyclonal (aa238-552) (PE) Antibody
Human
WB
PE Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
SPTLC3 / C20orf38 Rabbit anti-Human Polyclonal (aa238-552) (APC, Cy7) Antibody
Human
WB
APC, Cy7 Conjugated
100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676
SPTLC3 / C20orf38 Rabbit anti-Human Polyclonal (aa238-552) (Cy3) Antibody
Human
WB
Cy3 Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
E. coli
His-T7
38.7 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
E. coli
His-T7
58.4 kDa
10 µg/$285; 50 µg/$467; 100 µg/$747; 200 µg/$932; 1 mg/$2,058; 500 µg/$1,590; 5 mg/$3,263; 2 mg/$2,246
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$834
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$854
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