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This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described.
Gene Name: | spectrin, beta, erythrocytic |
Synonyms: | SPTB, Beta-I spectrin, EL3, HS2, HSPTB1, SPH2, Spectrin, beta, erythrocytic, Membrane cytoskeletal protein, SPTB1 |
Target Sequences: | NM_000347 NP_000338.3 P11277 |
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