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E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.
Gene Name: | tripartite motif containing 9 |
Family/Subfamily: | Tripartite Motif |
Synonyms: | TRIM9, KIAA0282, RING finger protein 91, SPRING, Tripartite motif containing 9, RNF91, Tripartite motif-containing 9 |
Target Sequences: | NM_015163 NP_055978.4 Q9C026 |
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