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SPPL2B

signal peptide peptidase like 2B

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity.

Gene Name: signal peptide peptidase like 2B
Family/Subfamily: Protease , Aspartic A22B
Synonyms: SPPL2B, Intramembrane protease 4, Presenilin-like protein 1, KIAA1532, PSH4, PSL1, SPP-like 2B, IMP-4, SNPPL2B
Target Sequences: AB040965 BAA96056.1 Q8TCT7

☰ Filters
Antibodies (14)
Primary (14)
SPPL2B (14)
Human (14)
Bovine (3)
Chimpanzee (3)
IHC (4)
IHC-P (4)
WB (10)
ELISA (4)
IF (1)
Peptide-ELISA (2)
rabbit (14)
IgG (8)
polyclonal pc (14)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
Unconjugated (5)
aa53-102 (4)
aa93-142 (4)
aa126-160 (1)
aa196-229 (1)
No (14)
SPPL2B Antibody - Immunofluorescence staining of A549 cells diluted at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C.The Secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
Select
SPPL2B Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
50 µg/$294; 100 µg/$360
Select
SPPL2B Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
SPPL2B Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
SPPL2B Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
SPPL2B Antibody - SPPL2B antibody SPPL2B(signal peptide peptidase-like 2B) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SPPL2B Rabbit anti-Human Polyclonal (aa93-142) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$424
SPPL2B Antibody - SPPL2B antibody SPPL2B(signal peptide peptidase-like 2B) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SPPL2B Rabbit anti-Human Polyclonal (aa93-142) (HRP) Antibody
Bovine, Human, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
SPPL2B Antibody - SPPL2B antibody SPPL2B(signal peptide peptidase-like 2B) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SPPL2B Rabbit anti-Human Polyclonal (aa93-142) (Biotin) Antibody
Bovine, Human, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
SPPL2B Antibody - SPPL2B antibody SPPL2B(signal peptide peptidase-like 2B) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SPPL2B Rabbit anti-Human Polyclonal (aa93-142) (FITC) Antibody
Bovine, Human, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
SPPL2B Antibody - Anti-SPPL2B Antibody (Center)at 1:2000 dilution + human cerebellum lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 65 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Select
SPPL2B Rabbit anti-Human Polyclonal (aa196-229) Antibody
Human
Peptide-ELISA, WB
Unconjugated
200 µl/$393
SPPL2B Antibody - All lanes: Anti-SPPL2B Antibody (N-Term) at 1:2000 dilution. Lane 1: HeLa whole cell lysate. Lane 2: HT-29 whole cell lysate. Lane 3: Jurkat whole cell lysate. Lane 4: KG-1 whole cell lysate. Lane 5: Ramos whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 65 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Select
SPPL2B Rabbit anti-Human Polyclonal (aa126-160) Antibody
Human
Peptide-ELISA, WB
Unconjugated
200 µl/$393
SPPL2B Antibody - Western blot of Human 293T. SPPL2B antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SPPL2B Rabbit anti-Human Polyclonal (aa53-102) Antibody
Human
WB
Unconjugated
100 µl/$424
SPPL2B Antibody - Western blot of Human 293T. SPPL2B antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SPPL2B Rabbit anti-Human Polyclonal (aa53-102) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$469
SPPL2B Antibody - Western blot of Human 293T. SPPL2B antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SPPL2B Rabbit anti-Human Polyclonal (aa53-102) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$469
SPPL2B Antibody - Western blot of Human 293T. SPPL2B antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SPPL2B Rabbit anti-Human Polyclonal (aa53-102) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$469
Viewing 1-14 of 14 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).