SPOP

speckle-type POZ protein

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL.

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Products

Proteins (14)

Type

Over-Expression Lysate (10)

Recombinant (4)

Target

SPOP (14)

Publications

No (14)

Tag

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (11)

Species

Human (9)

Source

293T Cells (5)

E. coli (1)

HEK 293 Cells (6)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human SPOP Protein (Recombinant GST, N-terminus) (aa301-374) - LS-G60708

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SPOP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92936

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

20 µg/$150

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Human SPOP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92939

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

20 µg/$150

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Human SPOP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92938

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

20 µg/$150

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Human SPOP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92940

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

20 µg/$150

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Human SPOP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92941

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

20 µg/$150

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SPOP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100070

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

100 µg/$494

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SPOP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121953

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

100 µg/$494

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SPOP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121955

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

100 µg/$494

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SPOP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121956

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

100 µg/$494

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SPOP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123559

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

100 µg/$494

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Human SPOP Protein (Recombinant His) - LS-G1229

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Human SPOP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72587

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

20 µg/$1,107

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Human SPOP Protein (Recombinant GST) (Full Length) - LS-G31138

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

68.5 kDa

Price:

2 µg/$439

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