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Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression.
Gene Name: | Spi-C transcription factor (Spi-1/PU.1 related) |
Synonyms: | SPIC, SPI-C, Transcription factor Spi-C |
Target Sequences: | NM_152323 NP_689536.1 Q8N5J4 |
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