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SPATA13

spermatogenesis associated 13

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

Gene Name: spermatogenesis associated 13
Synonyms: SPATA13, ARHGEF29, ASEF2, RP11-307N16.3, Spermatogenesis associated 13
Target Sequences: NM_001166271 NP_001159743.1 Q96N96

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Proteins (2)
Over-Expression Lysate (2)
SPATA13 (2)
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Myc-DDK (Flag) (2)
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HEK 293 Cells (1)
SPATA13 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
74.6 kDa
20 µg/$215
SPATA13 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
74.6 kDa
100 µg/$710
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).