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SPATA13
spermatogenesis associated 13
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
| Gene Name: | spermatogenesis associated 13 |
| Synonyms: | SPATA13, ARHGEF29, ASEF2, RP11-307N16.3, Spermatogenesis associated 13 |
| Target Sequences: | NM_001166271 NP_001159743.1 Q96N96 |
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