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Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that contains a consensus nuclear localization signal but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined.
Gene Name: | SPANX family, member D |
Synonyms: | SPANXD, SPANX family member E, SPANX family, member E, SPAN-Xe protein, SPANX-E, SPANXE |
Target Sequences: | NP_663698.1 Q8TAD1 |
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