SP100

SP100 nuclear antigen

Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.

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Products

Proteins (5)

Type

Recombinant (5)

Target

SP100 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (3)

Species

Human (3)

Mouse (1)

Rat (1)

Source

E. coli (3)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human SP100 Protein (Recombinant His-T7) (aa610-802) - LS-G11999

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.3 kDa

Price:

50 µg/$412; 10 µg/$276; 200 µg/$822; 100 µg/$657; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Mouse SP100 Protein (Recombinant His-T7) (aa261-465) - LS-G12000

Source:

E. coli

Tag:

His-T7

Molecular Weight:

27.2 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Rat SP100 Protein (Recombinant His-T7) (aa116-333) - LS-G23985

Source:

E. coli

Tag:

His-T7

Molecular Weight:

27.6 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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Human SP100 Protein (Recombinant GST, N-terminus) (aa1-98) - LS-G60185

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SP100 Protein (Recombinant GST) (Full Length) - LS-G30503

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

80.2 kDa

Price:

10 µg/$479; 25 µg/$670

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