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SOX4

SRY (sex determining region Y)-box 4

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.

Gene Name: SRY (sex determining region Y)-box 4
Family/Subfamily: Transcription factor
Synonyms: SOX4, EVI16, SRY-related HMG-box gene 4, Transcription factor SOX-4
Target Sequences: NM_003107 NP_003098.1 Q06945

Publications (4)

1
SOX4 interacts with plakoglobin in a Wnt3a-dependent manner in prostate cancer cells. Lai YH, Cheng J, Cheng D, Feasel ME, Beste KD, Peng J, Nusrat A, Moreno CS. BMC cell biology. 2011 12:50. (WB; Human) [Full Text Article] [PubMed:22098624] [PMC:PMC3227594]
2
A crucial epithelial to mesenchymal transition regulator, Sox4/Ezh2 axis is closely related to the clinical outcome in pancreatic cancer patients. Hasegawa S, Nagano H, Konno M, Eguchi H, Tomokuni A, Tomimaru Y, Asaoka T, Wada H, Hama N, Kawamoto K, Marubashi S, Nishida N, Koseki J, Mori M, Doki Y, Ishii H. International journal of oncology. 2016 48:145-52. (WB; Human) [Full Text Article] [PubMed:26648239]
3
BRAF/EZH2 Signaling Represses miR-129-5p Inhibition of SOX4 Thereby Modulating BRAFi Resistance in Melanoma. Kathleen Gebhardt, Bayram Edemir, Elisabeth Groß, Linda Nemetschke, Stefanie Kewitz-Hempel, Rose K C Moritz, Cord Sunderkötter, Dennis Gerloff. Cancers. 2021 May;13: [Full Text Article] [PubMed:34063443] [PMC:PMC8155874] Related Antibodies: LS-C499849.
4
Hypoxia-sensitive long noncoding RNA CASC15 promotes lung tumorigenesis by regulating the SOX4/ß-catenin axis. Jianyong Sun , Yanlu Xiong, Kuo Jiang, Bo Xin, Tongtong Jiang, Renji Wei, Yuankang Zou, Hong Tan, Tao Jiang, Angang Yang, Lintao Jia, Lei Wang. Journal of experimental & clinical cancer research : CR. 2021 Jan;40:12. [Full Text Article] [PubMed:33407675] [PMC:PMC7789733] Related Antibodies: LS-C97708.
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Proteins (4)
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SOX4 (4)
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GST, N-terminus (1)
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SOX4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
47.1 kDa
100 µg/$494
SOX4 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
SOX4 Protein - Purified recombinant protein SOX4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
47.1 kDa
20 µg/$1,107
SOX4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
47.1 kDa
20 µg/$150
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).