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SOX3
SRY (sex determining region Y)-box 3
Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.
| Gene Name: | SRY (sex determining region Y)-box 3 |
| Family/Subfamily: | Transcription factor |
| Synonyms: | SOX3, GHDX, MRGH, SOXB, Panhypopituitarism, PHPX, Sry-box3, PHP, Transcription factor SOX-3 |
| Target Sequences: | NM_005634 NP_005625.2 P41225 |
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