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SNX13
sorting nexin 13
SNX13 is a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking.
| Gene Name: | sorting nexin 13 |
| Synonyms: | SNX13, KIAA0713, Sorting nexin 13, RGS-PX1, Sorting nexin-13 |
| Target Sequences: | NM_015132 NP_055947.1 Q9Y5W8 |
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