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Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development.
|Gene Name:||small nuclear ribonucleoprotein polypeptide E|
|Synonyms:||SNRPE, B-raf, Sm protein E, SME, SnRNP-E, Sm-E|
|Target Sequences:||NM_003094 NP_003085.1 P62304|
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