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SNRPD1 / SMD1

small nuclear ribonucleoprotein D1 polypeptide 16kDa

Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA.

Gene Name: small nuclear ribonucleoprotein D1 polypeptide 16kDa
Synonyms: SNRPD1, SMD1, SnRNP core protein D1, SNRPD, Sm-D1, HsT2456, Sm-D autoantigen
Target Sequences: NM_006938 NP_008869.1 P62314

Publications (2)

1
G-Quadruplex Structures Colocalize with Transcription Factories and Nuclear Speckles Surrounded by Acetylated and Dimethylated Histones H3. Denisa Komurková, Alena Svobodová Kovaríková, Eva Bártová. International journal of molecular sciences. 2021 February;22: [Full Text Article] [PubMed:33671470] [PMC:PMC7922289] Related Antibodies: LS-C346290.
2
N6-Adenosine Methylation in RNA and a Reduced m3G/TMG Level in Non-Coding RNAs Appear at Microirradiation-Induced DNA Lesions. Alena Svobodová Kovaríková, Lenka Stixová, Aleš Kovarík, Denisa Komurková, Sona Legartová, Paolo Fagherazzi, Eva Bártová. Cells. 2020 Feb;9:360. [Full Text Article] [PubMed:32033081] [PMC:PMC7072662] Related Antibodies: LS-C346290.

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
SNRPD1 / SMD1 (4)
No (4)
GST (1)
His-T7 (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
SNRPD1 / SMD1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
13.1 kDa
100 µg/$494
SNRPD1 / SMD1 Protein - Recombinant Small Nuclear Ribonucleoprotein Polypeptide D1 By SDS-PAGE
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E. coli
His-T7
17.1 kDa
50 µg/$442; 10 µg/$281; 200 µg/$882; 100 µg/$705; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
SNRPD1 / SMD1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
13.1 kDa
20 µg/$150
SNRPD1 / SMD1 Protein - 12.5% SDS-PAGE of human SNRPD1 stained with Coomassie Blue
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Wheat Germ Extract
GST
39.7 kDa
10 µg/$479; 25 µg/$670
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).