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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SNCA / Alpha-Synuclein

synuclein, alpha (non A4 component of amyloid precursor)

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

Gene Name: synuclein, alpha (non A4 component of amyloid precursor)
Synonyms: SNCA, Alpha-synuclein, PARK4, PD1, Synuclein alpha-140, NACP, PARK1
Target Sequences: NM_000345 NP_000336.1 P37840

Publications (3)

1
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Giasson BI, Duda JE, Murray IV, Chen Q, Souza JM, Hurtig HI, Ischiropoulos H, Trojanowski JQ, Lee VM. Science (New York, N.Y.). 2000 290:985-9. [PubMed:11062131]
2
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications. Qing H, Wong W, McGeer EG, McGeer PL. Biochemical and biophysical research communications. 2009 387:149-52. (WB) [PubMed:19576176]
3
Determining nuclear localization of alpha-synuclein in mouse brains. Huang Z, Xu Z, Wu Y, Zhou Y. Neuroscience. 2011 199:318-32. [PubMed:22033456] [PMC:PMC3237852]

Filtered by: None
Type
Over-Expression Lysate (10)
Recombinant (43)
Target
SNCA / Alpha-Synuclein (53)
Tag
6His + SUMO,N-terminus (1)
6His,N-terminus (3)
GST (2)
GST,N-terminus (2)
His (4)
His, N-Terminal (1)
Myc + DDK (14)
Species
Crab-eating macaque (1)
Cynomolgus monkey (1)
Human (39)
Mouse (5)
Rat (2)
Source
293T Cells (5)
E. coli (35)
HEK 293 Cells (9)
Wheat Germ Extract (2)
Yeast (2)
Purification
Purified (34)
Low Endotoxin Level
Low endotoxin level (7)
Publications
No (53)
Showing 1-25 of 53 results

Cynomolgus monkey SNCA / Alpha-Synuclein Protein (Recombinant His) (Full Length) - LS-G23140
Yeast
His
16.5 kD
1000µg 0.5mg/ml  $2,205.00; 500µg  $1,395.00; 200µg 0.4mg/ml  $980.00; 50µg 0.2mg/ml  $395.00; 10µg  $325.00; 100µg  $605.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

Mouse SNCA / Alpha-Synuclein Protein (Recombinant) - LS-G849
E. coli
None
100µg 1mg/ml  $315.00; 0.5mg 1mg/ml  $695.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

Human SNCA / Alpha-Synuclein Protein (Recombinant) - LS-G3556
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
100µg 1mg/ml  $265.00; 1mg 1mg/ml  $475.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

Human SNCA / Alpha-Synuclein Protein (Recombinant GST) (Full Length) - LS-G30476
Wheat Germ Extract
GST
41.14 kDa
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE of human SNCA stained with Coomassie Blue

Human SNCA / Alpha-Synuclein Protein (Recombinant 6His,N-terminus) (Full Length) - LS-G21199
E. coli
6His,N-terminus
18.6 kD
1000µg  $1,245.00; 500µg  $785.00; 200µg  $475.00; 50µg  $275.00; 10µg  $235.00; 100µg  $355.00

Human SNCA / Alpha-Synuclein Protein (Recombinant GST) (Full Length) - LS-G22347
E. coli
GST
41.8 kD
1000µg  $1,245.00; 500µg  $785.00; 200µg  $475.00; 50µg  $275.00; 10µg  $235.00; 100µg  $355.00

Human SNCA / Alpha-Synuclein Protein (Recombinant His) (Full Length) - LS-G23139
Yeast
His
16.5 kD
1000µg  $1,500.00; 500µg  $950.00; 200µg  $560.00; 50µg  $295.00; 10µg  $255.00; 100µg  $385.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

Human SNCA / Alpha-Synuclein Protein (Recombinant GST,N-terminus) (aa31-140) - LS-G60160
Wheat Germ Extract
GST,N-terminus
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE Stained with Coomassie Blue.

SNCA / Alpha-Synuclein Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G127022
HEK 293 Cells
Myc + DDK
11.2 kDa
100µg  $365.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human SNCA / Alpha-Synuclein Protein (Recombinant His, N-Terminal) (Lys23-Ala140) - LS-G133013
E. coli
His, N-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
17kDa
10µg  $275.00; 50µg  $435.00; 200µg  $830.00; 100µg  $665.00; 1mg  $2,475.00
Recombinant Synuclein Alpha (SNCa) by SDS-PAGE

SNCA / Alpha-Synuclein Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G114744
HEK 293 Cells
Myc + DDK
11.2 kDa
100µg  $365.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

SNCA / Alpha-Synuclein Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G128510
HEK 293 Cells
Myc + DDK
14.3 kDa
100µg  $365.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

SNCA / Alpha-Synuclein Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G128511
HEK 293 Cells
Myc + DDK
14.3 kDa
100µg  $365.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Mouse SNCA / Alpha-Synuclein Protein (Recombinant) (Met1-Ala140) - LS-G40172
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
14.5kD
10µg  $195.00; 50µg  $235.00; 500µg  $635.00; 1mg  $890.00

Human SNCA / Alpha-Synuclein Protein (Recombinant 6His,N-terminus) (Met1-Ala140) - LS-G39821
E. coli
6His,N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.7kD
10µg  $195.00; 50µg  $235.00; 500µg  $680.00; 1mg  $1,095.00

Human SNCA / Alpha-Synuclein Protein (Recombinant) (Met1-Ala140) - LS-G39680
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
14.7kD
10µg  $185.00; 50µg  $225.00; 500µg  $635.00; 1mg  $995.00

Mouse SNCA / Alpha-Synuclein Protein (Recombinant) - LS-G20255
E. coli
None
14.4 kDa
5µg  $195.00; 20µg  $255.00; 1mg  $2,850.00

Human SNCA / Alpha-Synuclein Protein (Recombinant) - LS-G19327
E. coli
None
8.4 kDa
10µg  $195.00; 50µg  $255.00; 1mg  $1,890.00

Human SNCA / Alpha-Synuclein Protein (Recombinant) - LS-G19338
E. coli
None
5.2 kDa
10µg  $195.00; 50µg  $255.00; 1mg  $1,890.00

Human SNCA / Alpha-Synuclein Protein (Recombinant) - LS-G19294
E. coli
None
14.5 kDa
10µg  $195.00; 50µg  $255.00; 1mg  $1,890.00

Human SNCA / Alpha-Synuclein Protein (Recombinant) - LS-G19305
E. coli
None
11.9 kDa
10µg  $195.00; 50µg  $255.00; 1mg  $1,890.00

Human SNCA / Alpha-Synuclein Protein (Recombinant) - LS-G19272
E. coli
None
14.4 kDa
10µg  $195.00; 50µg  $255.00; 1mg  $1,890.00

Human SNCA / Alpha-Synuclein Protein (Recombinant) - LS-G19283
E. coli
None
14.4 kDa
10µg  $195.00; 50µg  $255.00; 1mg  $1,890.00

Human SNCA / Alpha-Synuclein Protein (Recombinant) - LS-G19316
E. coli
None
11.3 kDa
10µg  $195.00; 1mg  $1,890.00; 20µg  $255.00

Human SNCA / Alpha-Synuclein Protein (Recombinant) - LS-G19349
E. coli
None
6.1 kDa
10µg  $195.00; 50µg  $255.00; 1mg  $1,890.00
Showing 1-25 of 53 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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