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SNCA / Alpha-Synuclein

synuclein, alpha (non A4 component of amyloid precursor)

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

Gene Name: synuclein, alpha (non A4 component of amyloid precursor)
Synonyms: SNCA, Alpha-synuclein, PARK4, PD1, Synuclein alpha-140, NACP, PARK1, aSynuclein, a-Synuclein
Target Sequences: NM_000345 NP_000336.1 P37840

Publications (7)

1
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Giasson BI, Duda JE, Murray IV, Chen Q, Souza JM, Hurtig HI, Ischiropoulos H, Trojanowski JQ, Lee VM. Science (New York, N.Y.). 2000 290:985-9. [PubMed:11062131]
2
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications. Qing H, Wong W, McGeer EG, McGeer PL. Biochemical and biophysical research communications. 2009 387:149-52. (WB) [PubMed:19576176]
3
Determining nuclear localization of alpha-synuclein in mouse brains. Huang Z, Xu Z, Wu Y, Zhou Y. Neuroscience. 2011 199:318-32. [PubMed:22033456] [PMC:PMC3237852]
4
Reversible Conformational Conversion of a-Synuclein into Toxic Assemblies by Glucosylceramide. Zunke F, Moise AC, Belur NR, Gelyana E, Stojkovska I, Dzaferbegovic H, Toker NJ, Jeon S, Fredriksen K, Mazzulli JR. Neuron. 2018 January;97:92-107. [Full Text Article] [PubMed:29290548] [PMC:PMC6013314]
5
Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features. Mélissa Jasmin, Eun Hee Ahn, Merja H Voutilainen, Joanna Fombonne, Catherine Guix, Tuulikki Viljakainen, Seong Su Kang, Li-Ying Yu, Mart Saarma, Patrick Mehlen, Keqiang Ye. The EMBO journal. 2021 February;40:e105537. [Full Text Article] [PubMed:33351190] [PMC:PMC7849168] Related Antibodies: LS-C380861.
6
Facile single-molecule pull-down assay for analysis of endogenous proteins. Benjamin Croop, Kyu Young Han. Physical biology. 2019 March;16:035002. [Full Text Article] [PubMed:30769341] [PMC:PMC9238377] Related Antibodies: LS-C370648.
7
UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease. Guiqin Chen, Eun Hee Ahn, Seong Su Kang, Yiyuan Xia, Xia Liu, Zhaohui Zhang, Keqiang Ye. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022 March;9:e2103396. [Full Text Article] [PubMed:35023303] [PMC:PMC8895126] Related Antibodies: LS-C380861.
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).