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SNARK / NUAK2
NUAK family, SNF1-like kinase, 2
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.
| Gene Name: | NUAK family, SNF1-like kinase, 2 |
| Family/Subfamily: | Protein Kinase , CAMKL |
| Synonyms: | NUAK2, OMPHK2, SNARK, Omphalocele kinase 2, SNF1/AMP kinase-related kinase, NUAK family SNF1-like kinase 2 |
| Target Sequences: | BC017306 BAC11234.1 Q9H093 |
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