SNAI1 / SNAIL-1

snail family zinc finger 1

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

SNAI1 / SNAIL-1 (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human SNAI1 / SNAIL-1 Protein (Recombinant GST, N-terminus) (aa121-230) - LS-G60153

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SNAI1 / SNAIL-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87021

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.9 kDa

Price:

20 µg/$150

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Human SNAI1 / SNAIL-1 Protein (Recombinant GST) (Full Length) - LS-G30470

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

55.5 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SNAI1 / SNAIL-1 Protein (Recombinant His-T7) (aa1-264) - LS-G26050

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.8 kDa

Price:

10 µg/$266; 50 µg/$349; 100 µg/$555; 200 µg/$692; 1 mg/$1,709; 500 µg/$1,286; 5 mg/$2,659; 2 mg/$1,886

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Human SNAI1 / SNAIL-1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70421

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.9 kDa

Price:

20 µg/$1,107

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SNAI1 / SNAIL-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100695

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.9 kDa

Price:

100 µg/$494

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Human SNAI1 / SNAIL-1 Protein (Recombinant His) - LS-G2635

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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