SMURF2

SMAD specific E3 ubiquitin protein ligase 2

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

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Products

ELISA Kits (3)

Type

Competitive EIA (1)

Custom (1)

Sandwich (1)

Target

SMURF2 (3)

Reactivity

Human (1)

Mouse (1)

Rat (1)

Format

96-Well Strip Plate (3)

Publications

No (3)

Sample Type

Cell Lysates (1)

Plasma (2)

Serum (2)

Tissue Homogenates (1)

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Rat SMURF2 (Sandwich ELISA) ELISA Kit - LS-F39097

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$965

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Mouse SMURF2 (Custom ELISA) ELISA Kit - LS-F65194

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human SMURF2 (Competitive EIA) ELISA Kit - LS-F66470

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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