SMUG1

single-strand-selective monofunctional uracil-DNA glycosylase 1

Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

SMUG1 (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His-SUMO (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human SMUG1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86343

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.7 kDa

Price:

20 µg/$150

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SMUG1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114032

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.7 kDa

Price:

100 µg/$494

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Human SMUG1 Protein (Recombinant His-SUMO) (Full Length) - LS-G21725

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

35.61 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human SMUG1 Protein (Recombinant His-T7) (aa1-270) - LS-G25858

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.6 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human SMUG1 Protein (Recombinant GST) (Full Length) - LS-G32904

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

46 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SMUG1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70139

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.7 kDa

Price:

20 µg/$1,107

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Human SMUG1 Protein (Recombinant GST, N-terminus) (aa2-78) - LS-G62036

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SMUG1 Protein (Recombinant His) - LS-G2065

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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