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SMPD1 / Acid Sphingomyelinase

sphingomyelin phosphodiesterase 1, acid lysosomal

Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity.

Gene Name: sphingomyelin phosphodiesterase 1, acid lysosomal
Family/Subfamily: Phosphodiesterase - Other , not assigned-Phosphodiesterase - Other
Synonyms: SMPD1, Acid sphingomyelinase, ASM, NPD, ASMASE
Target Sequences: NM_000543 NP_000534.3 P17405

Publications (3)

1
Regulation of the amount of ceramide-1-phosphate synthesized in differentiated human podocytes. Shamroop Kumar Mallela, Alla Mitrofanova, Sandra Merscher, Alessia Fornoni. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2019 December;1864:158517. [Full Text Article] [PubMed:31487557] [PMC:PMC6832884] Related Antibodies: LS-C334919.
2
Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseases. Yue-Hong Chen, Rong-Han Liu, Ya-Zhou Cui, Aubryanna Hettinghouse, Wen-Yu Fu, Lei Zhang, Chen Zhang, Chuan-Ju Liu. Arthritis research & therapy. 2022 January;24:27. [Full Text Article] [PubMed:35045889] [PMC:PMC8767691] Related Antibodies: LS-C334919.
3
Endothelial Acid Sphingomyelinase Promotes NLRP3 Inflammasome and Neointima Formation During Hypercholesterolemia. Xinxu Yuan, Owais M Bhat, Yao Zou, Xiang Li, Yang Zhang, Pin-Lan Li. Journal of lipid research. 2022 October;63:100298. [Full Text Article] [PubMed:36252682] [PMC:PMC9672920] Related Antibodies: LS-C334919.

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Products
Antibodies (37)
Primary (37)
SMPD1 / Acid Sphingomyelinase (37)
Human (37)
Mouse (16)
Rat (6)
Bovine (1)
Sheep (1)
IHC (13)
IHC-P (5)
WB (34)
Flo (6)
ELISA (13)
IF (3)
IP (1)
Neut (1)
Peptide-ELISA (1)
rabbit (29)
mouse (7)
goat (1)
Product Group
IHCPlus (4)
IgG (12)
IgG1 (5)
IgG2a (1)
IgG2a,k (1)
monoclonal mc (7)
polyclonal pc (30)
09 (1)
4H2 (1)
OTI10C5 (2)
OTI3H7 (2)
APC (1)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (3)
Carrier-free (2)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (2)
Preservative Free (1)
Unconjugated (22)
aa319-579 (8)
aa391-419 (7)
aa62-341 (4)
aa79-128 (4)
Internal (1)
aa396-445 (1)
aa70-340 (1)
No (36)
Yes (1)
SMPD1 / Acid Sphingomyelinase Antibody - Immunofluorescence analysis of HeLa cells.
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa70-340) Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
20 µl/$275; 100 µl/$389
SMPD1 / Acid Sphingomyelinase Antibody - Human Colon, Submucosal Plexus: Formalin-Fixed, Paraffin-Embedded (FFPE)
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Sheep, Bovine, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
SMPD1 / Acid Sphingomyelinase Antibody - Anti-SMPD1 / Acid Sphingomyelinase antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa391-419) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$460
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SMPD1 / Acid Sphingomyelinase Mouse anti-Human Monoclonal Antibody
Human
ELISA, IP, Neut
Unconjugated
100 µg/$896
SMPD1 / Acid Sphingomyelinase Antibody - Anti-SMPD1 / Acid Sphingomyelinase antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa396-445) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
SMPD1 / Acid Sphingomyelinase Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
SMPD1 / Acid Sphingomyelinase Antibody - SMPD1 / Acid Sphingomyelinase antibody Western Blot of THP-1. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa79-128) Antibody
Human
WB
Unconjugated
100 µl/$424
SMPD1 / Acid Sphingomyelinase Antibody - SMPD1 / Acid Sphingomyelinase antibody Western Blot of THP-1. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa79-128) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$469
SMPD1 / Acid Sphingomyelinase Antibody - IHC of paraffin-embedded Human Ovary tissue using anti-SMPD1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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SMPD1 / Acid Sphingomyelinase Mouse anti-Human Monoclonal (aa62-341) (OTI3H7) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
SMPD1 / Acid Sphingomyelinase Antibody - IHC of paraffin-embedded Human Ovary tissue using anti-SMPD1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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SMPD1 / Acid Sphingomyelinase Mouse anti-Human Monoclonal (aa62-341) (Carrier-free) (OTI3H7) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
SMPD1 / Acid Sphingomyelinase Antibody - Western blot of recombinant SMPD1 / Acid Sphingomyelinase.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa319-579) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
SMPD1 / Acid Sphingomyelinase Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SMPD1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SMPD1.
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SMPD1 / Acid Sphingomyelinase Mouse anti-Human Monoclonal (aa62-341) (OTI10C5) Antibody
Human
WB
Unconjugated
100 µl/$434
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa391-419) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa391-419) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa391-419) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa391-419) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa391-419) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal (aa391-419) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SMPD1 / Acid Sphingomyelinase Antibody - Immunohistochemistry of paraffin-embedded Rat ovary using SMPD1 / ASM Polyclonal Antibody at dilution of 1:100 (40x lens).
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
SMPD1 / Acid Sphingomyelinase Antibody - Western Blot analysis of SMPD1 expression in transfected 293T cell line by SMPD1 monoclonal antibody (M01), clone 4H2.Lane 1: SMPD1 transfected lysate(39.6 KDa).Lane 2: Non-transfected lysate.
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SMPD1 / Acid Sphingomyelinase Mouse anti-Human Monoclonal (4H2) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
SMPD1 / Acid Sphingomyelinase Antibody - Western blot of acid sphingomyelinase antibody on normal human brain lysate (7 ug/lane). Antibody used at 1 ug/ml (1) and 0.5 ug/ml (2) and detected using mouse anti-rabbit antibody at 1:75k dilution and visualized using Pierce West Femto substrate.
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SMPD1 / Acid Sphingomyelinase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$572
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SMPD1 / Acid Sphingomyelinase Goat anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$930
Viewing 1-25 of 37 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).