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SMOX / PAO

Spermine Oxidase

Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism.

Gene Name: Spermine Oxidase
Synonyms: SMOX, C20orf16, DJ779E11.1, PAO-1, PAOH1, PAO, Spermine oxidase, Polyamine oxidase 1
Target Sequences: AK000753 BAA91360.1 Q9NWM0

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Proteins (10)
Over-Expression Lysate (6)
Recombinant (4)
SMOX / PAO (10)
No (10)
His (1)
His-S (1)
His-SUMO (1)
Myc-DDK (Flag) (7)
Human (5)
Mouse (2)
293T Cells (3)
E. coli (2)
HEK 293 Cells (4)
Yeast (1)
SMOX / PAO Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
61.6 kDa
100 µg/$710
SMOX / PAO Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
55.9 kDa
100 µg/$494
SMOX / PAO Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
59.1 kDa
100 µg/$710
SMOX / PAO Protein
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Yeast
His
63.85 kD
1 mg/$1,683; 100 µg/$499; 20 µg/$364
SMOX / PAO Protein - Recombinant Spermine Oxidase By SDS-PAGE
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E. coli
His-S
21.6 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
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E. coli
His-SUMO
77.81 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
SMOX / PAO Protein - Purified recombinant protein SMOX was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
55.9 kDa
20 µg/$1,107
SMOX / PAO Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
61.6 kDa
20 µg/$215
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293T Cells
Myc-DDK (Flag)
55.9 kDa
20 µg/$150
SMOX / PAO Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
59.1 kDa
20 µg/$215
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).