SMAD7

SMAD family member 7

Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

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Proteins (3)

Type

Over-Expression Lysate (1)

Recombinant (2)

Target

SMAD7 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human SMAD7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115654

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.2 kDa

Price:

100 µg/$494

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Human SMAD7 Protein (Recombinant GST, N-terminus) (aa160-260) - LS-G59167

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SMAD7 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67564

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.2 kDa

Price:

20 µg/$1,107

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