SMAD4

SMAD family member 4

In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

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Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

SMAD4 (8)

Publications

No (8)

Tag

6His, C-terminus (2)

His (1)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

E. coli (5)

HEK 293 Cells (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (2)

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Human SMAD4 Protein (Recombinant 6His, C-terminus) (Met1-Asp552) - LS-G139473

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

61.5 kDa

Price:

10 µg/$289; 50 µg/$414

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Human SMAD4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75624

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.3 kDa

Price:

20 µg/$150

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Human SMAD4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65470

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.3 kDa

Price:

20 µg/$1,107

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SMAD4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100532

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.3 kDa

Price:

100 µg/$494

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Human SMAD4 Protein (Recombinant His) - LS-G3553

Source:

E. coli

Tag:

His

Price:

100 µg/$317; 500 µg/$526; 20 µg/$245

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Human SMAD4 Protein (Recombinant 6His, C-terminus) (Met1-Asp552) - LS-G39666

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

61.5kD

Price:

10 µg/$243; 50 µg/$420; 500 µg/$1,585; 1 mg/$2,157

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Human SMAD4 Protein (Recombinant His-T7) (aa323-552) - LS-G14465

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.8 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Mouse SMAD4 Protein (Recombinant His-T7) (aa9-231) - LS-G14466

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.3 kDa

Price:

10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170

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