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SLCO1B1 / OATP2

solute carrier organic anion transporter family, member 1B1

Mediates the Na+-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.

Gene Name: solute carrier organic anion transporter family, member 1B1
Family/Subfamily: Transporter , Organic anion transporter
Synonyms: SLCO1B1, OATP-2, Oatp2, OATP-C, OATPC, ORGANIC ANION TRANSPORTER C, RLST-1, OATP1B1, SLC21A6
Target Sequences: NM_006446 NP_006437.3 Q9Y6L6

Publications (1)

1
Down-regulation of OATP1B proteins correlates with hyperbilirubinemia in advanced cholestasis. Sticova E, Lodererova A, van de Steeg E, Frankova S, Kollar M, Lanska V, Kotalova R, Dedic T, Schinkel AH, Jirsa M. International journal of clinical and experimental pathology. 2015 8:5252-62. (WB; Human) [PubMed:26191226] [PMC:PMC4503098] Related Antibodies: LS-C8522, LS-C8521.

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Proteins (3)
Over-Expression Lysate (2)
Recombinant (1)
SLCO1B1 / OATP2 (3)
No (3)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
SLCO1B1 / OATP2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
SLCO1B1 / OATP2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
76.3 kDa
20 µg/$215
SLCO1B1 / OATP2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
76.3 kDa
100 µg/$710
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).