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SLC7A5 / CD98 Light Chain

solute carrier family 7 (amino acid transporter light chain, L system), member 5

Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts.

Gene Name: solute carrier family 7 (amino acid transporter light chain, L system), member 5
Family/Subfamily: Transporter , Cationic amino acid transporter
Synonyms: SLC7A5, 4F2 LC, 4F2 light chain, 4F2LC, CD98, CD98 light chain, CD98LC, D16S469E, Integral membrane protein E16, Membrane protein E16, MPE16, LAT1, E16, HLAT1, TA1
Target Sequences: NM_003486 NP_003477.4 Q01650

Publications (1)

1
Evaluation of 3-l- and 3-d-[18<sup>F]Fluorophenylalanines as PET Tracers for Tumor Imaging. Felicia Krämer, Benedikt Gröner, Chris Hoffmann, Austin Craig, Melanie Brugger, Alexander Drzezga, Marco Timmer, Felix Neumaier, Boris D Zlatopolskiy, Heike Endepols, Bernd Neumaier. Cancers. 2021 November;13:6030. [Full Text Article] [PubMed:34885141] [PMC:PMC8656747] Related Antibodies: LS-B15706.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).