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SLC4A8 / NBC
solute carrier family 4, sodium bicarbonate cotransporter, member 8
Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3- exchange with a Na+:HCO3- stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3- from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3- into the cells. Also mediates lithium-dependent HCO3- cotransport. May be regulated by osmolarity.
| Gene Name: | solute carrier family 4, sodium bicarbonate cotransporter, member 8 |
| Family/Subfamily: | Transporter , Anion exchanger |
| Synonyms: | SLC4A8, K-NBC3, KIAA0739, KNBC3, NBC3, NDCBE, NDCBE1, Nbc-3, NBC |
| Target Sequences: | NM_004858 NP_004849.2 Q2Y0W8 |
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