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SLC29A1 / ENT1

solute carrier family 29 (equilibrative nucleoside transporter), member 1

SLC29A1 / ENT1 is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.

Gene Name: solute carrier family 29 (equilibrative nucleoside transporter), member 1
Family/Subfamily: Transporter , Equilibrative nucleoside transporter
Synonyms: SLC29A1, ENT1, HENT1
Target Sequences: NM_004955 NP_004946.1 Q99808

Publications (4)

1
Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. Grenz A, Bauerle JD, Dalton JH, Ridyard D, Badulak A, Tak E, McNamee EN, Clambey E, Moldovan R, Reyes G, Klawitter J, Ambler K, Magee K, Christians U, Brodsky KS, Ravid K, Choi DS, Wen J, Lukashev D, Blackburn MR, Osswald H, Coe IR, Nrnberg B, Haase VH, X. The Journal of clinical investigation. 2012 122:693-710. [PubMed:22269324] [PMC:PMC3266792] Related Antibodies: LS-C96639.
2
Levels of human equilibrative nucleoside transporter-1 are higher in proliferating regions of A549 tumor cells grown as tumor xenografts in vivo. Plotnik DA, Asher C, Chu SK, Miyaoka RS, Garwin GG, Johnson BW, Li T, Krohn KA, Schwartz JL. Nuclear medicine and biology. 2012 39:1161-6. (IHC; Human) [Full Text Article] [PubMed:22985987] [PMC:PMC3478396] Related Antibodies: LS-B3385.
3
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Zheng X, Carstens JL, Kim J, Scheible M, Kaye J, Sugimoto H, Wu CC, LeBleu VS, Kalluri R. Nature. 2015 527:525-530. (IHC; Mouse) [Full Text Article] [PubMed:26560028] [PMC:PMC4849281] Related Antibodies: LS-B3385.
4
The combination of everolimus and zoledronic acid increase the efficacy of gemcitabine in a mouse model of pancreatic adenocarcinoma. Vitellius C, Fizanne L, Menager-Tabourel E, Nader J, Baize N, Laly M, Lermite E, Bertrais S, Caroli-Bosc FX. Oncotarget. 2018 June;9:28069-28082. [Full Text Article] [PubMed:29963262] [PMC:PMC6021353] Related Antibodies: LS-C178673.
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SLC29A1 / ENT1 (5)
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SLC29A1 / ENT1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
50 kDa
100 µg/$710
SLC29A1 / ENT1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
50 kDa
100 µg/$710
SLC29A1 / ENT1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
50 kDa
100 µg/$494
SLC29A1 / ENT1 Protein - 12.5% SDS-PAGE of human SLC29A1 stained with Coomassie Blue
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Wheat Germ Extract
GST
76.6 kDa
2 µg/$439
SLC29A1 / ENT1 Protein - Purified recombinant protein SLC29A1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
50 kDa
20 µg/$1,107
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).