SLC26A5

solute carrier family 26 (anion exchanger), member 5

Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site.

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ELISA Kits (3)

Type

Sandwich (3)

Target

SLC26A5 (3)

Reactivity

Human (1)

Mouse (1)

Rat (1)

Format

96-Well Strip Plate (3)

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Plasma (2)

Serum (2)

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Mouse SLC26A5 (Sandwich ELISA) ELISA Kit - LS-F65693

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Rat SLC26A5 (Sandwich ELISA) ELISA Kit - LS-F65278

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

15.6 - 1000 pg/ml

Price:

1 Plate/$669

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Human SLC26A5 (Sandwich ELISA) ELISA Kit - LS-F66713

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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