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SLC25A13 / CITRIN is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in this gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene Name: | solute carrier family 25 (aspartate/glutamate carrier), member 13 |
Family/Subfamily: | Transporter , Mitochondrial carrier |
Synonyms: | SLC25A13, CITRIN, CTLN2, ARALAR2 |
Target Sequences: | NM_014251 NP_055066.1 Q9UJS0 |
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