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SLC24A2 / NCKX2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.
| Gene Name: | solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 |
| Family/Subfamily: | Transporter , Calcium:cation antiporter |
| Synonyms: | SLC24A2, NCKX2, Retinal cone Na-Ca+K exchanger |
| Target Sequences: | NM_020344 NP_065077.1 Q9UI40 |
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