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SLC1A5 / ASCT2

solute carrier family 1 (neutral amino acid transporter), member 5

Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed:10051606, PubMed:10196349).

Gene Name:	solute carrier family 1 (neutral amino acid transporter), member 5
Family/Subfamily:	Transporter , Sodium:dicarboxylate symporter
Synonyms:	SLC1A5, ATBO, ASCT2, ATB0, Baboon M7 virus receptor, AAAT, M7VS1, M7V1, R16, RDRC, RD114 virus receptor, RDR, ATB(0)
Target Sequences:	NM_005628 NP_005619.1 Q15758

Publications (2)

The clinical and prognostic correlation of HRNPM and SLC1A5 in pathogenesis and prognosis in epithelial ovarian cancer. Bjersand K, Seidal T, Sundström-Poromaa I, Åkerud H, Skirnisdottir I. PloS one. 2017 June;12:e0179363. (Human) [Full Text Article] [PubMed:28609484] [PMC:PMC5469483] Related Antibodies: LS-A9042.

cDNA sequence and tissue distribution of canine Na-dependent neutral amino acid transporter 2 (ASCT 2). Hideharu Ochiai, Ken Onda, Kikumi Ogihara, Yuko Naya, Hiroki Sugiyama, Takuya Maruo. The Journal of veterinary medical science. 2012 November;74:1505-10. [Full Text Article] [PubMed:22785178] Related Antibodies: LS-C31887.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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