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Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.
Gene Name: | solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 |
Family/Subfamily: | Transporter , Sodium:sulfate symporter |
Synonyms: | SLC13A3, HNaDC3, NaDC-3, NADC3, SDCT2 |
Target Sequences: | NM_022829 NP_073740.2 Q8WWT9 |
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