SLC12A3 / TSC

solute carrier family 12 (sodium/chloride transporter), member 3

SLC12A3 / TSC is a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

SLC12A3 / TSC (5)

Publications

No (5)

Tag

His (2)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Purification

Purified (1)

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Human SLC12A3 / TSC Protein (Recombinant His) (aa3-146) - LS-G15456

Source:

E. coli

Tag:

His

Molecular Weight:

17.4 kDa

Price:

10 µg/$274; 50 µg/$400; 100 µg/$637; 200 µg/$797; 1 mg/$1,870; 500 µg/$1,424; 5 mg/$2,832; 2 mg/$2,053

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Human SLC12A3 / TSC Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79134

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

113.7 kDa

Price:

20 µg/$215

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SLC12A3 / TSC Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123253

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

113.7 kDa

Price:

100 µg/$710

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Human SLC12A3 / TSC Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67102

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

113.7 kDa

Price:

20 µg/$1,107

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Human SLC12A3 / TSC Protein (Recombinant His) (aa867-1024) - LS-G15455

Source:

E. coli

Tag:

His

Molecular Weight:

20.0 kDa

Price:

10 µg/$274; 50 µg/$400; 100 µg/$637; 200 µg/$797; 1 mg/$1,870; 500 µg/$1,424; 5 mg/$2,832; 2 mg/$2,053

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