SKP1

S-phase kinase-associated protein 1

Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and TELO2. SCF(FBXO10) direct ubiquitination of BCL2.

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Products

Proteins (11)

Type

Over-Expression Lysate (4)

Recombinant (7)

Target

SKP1 (11)

Publications

No (11)

Tag

GST (2)

GST, N-terminus (1)

His, N-Terminal (1)

His-T7 (1)

Myc-DDK (Flag) (5)

Species

Human (9)

Source

293T Cells (2)

E. coli (4)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human SKP1 Protein (Recombinant GST) (Full Length) - LS-G21191

Source:

E. coli

Tag:

GST

Molecular Weight:

34.52 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human SKP1 Protein (Recombinant) - LS-G653

Source:

E. coli

Tag:

None

Price:

100 µg/$342; 500 µg/$641; 20 µg/$254

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Human SKP1 Protein (Recombinant GST, N-terminus) (aa53-160) - LS-G60102

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SKP1 Protein (Recombinant His, N-Terminal) - LS-G144300

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

17.9 kDa

Price:

50 µg/$419

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Human SKP1 Protein (Recombinant GST) (Full Length) - LS-G30417

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

43.34 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SKP1 Protein (Recombinant His-T7) (aa1-163) - LS-G25664

Source:

E. coli

Tag:

His-T7

Molecular Weight:

22.4 kDa

Price:

10 µg/$279; 50 µg/$430; 100 µg/$687; 200 µg/$857; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142

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Human SKP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71361

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

18.5 kDa

Price:

20 µg/$1,107

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SKP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105637

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

18.5 kDa

Price:

100 µg/$494

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SKP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114979

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.9 kDa

Price:

100 µg/$494

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Human SKP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89580

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

18.5 kDa

Price:

20 µg/$150

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Human SKP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89581

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.9 kDa

Price:

20 µg/$150

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